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question based on it.
Is gene editing ethical?
Gene editing is the modification of DNA sequences in living
cells. What that means in reality is that researchers can
either add mutations or substitute genes in cells or
organisms.
Gene editing holds the key to preventing or treating
debilitating genetic diseases, giving hope to millions of
people around the world. Yet the same technology could
unlock the path to designing our future children, enhancing
their genome by selecting desirable traits such as height,
eye color, and intelligence.
While this concept is not new, a real breakthrough came 5
years ago when several scientists saw the potential of a
system called CRISPR/Cas9 to edit the human genome.
CRISPR/Cas9 allows us to target specific locations in the
genome with much more precision than previous
techniques. This process allows a faulty gene to be replaced
with a non-faulty copy, making this technology attractive to
those looking to cure genetic diseases.
The technology is not foolproof, however. Scientists have
been modifying genes for decades, but there are always
trade-offs. We have yet to develop a technique that works
100 percent and doesn't lead to unwanted and
uncontrollable mutations in other locations in the genome.
In a laboratory experiment, these so-called off-target effects
are not the end of the world. But when it comes to gene
editing in humans, this is a major stumbling block.
The fact that gene editing is possible in human embryos has
opened a Pandora's box of ethical issues.
Here, the ethical debate around gene editing really gets off
the ground.
When gene editing is used in embryos — or earlier, on the
sperm or egg of carriers of genetic mutations — it is called
germline gene editing. The big issue here is that it affects
both the individual receiving the treatment and their future
children.
This is a potential game-changer as it implies that we may
be able to change the genetic makeup of entire generations
on a permanent basis.